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Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Moncada, Salvador |
| Copyright Year | 2005 |
| Abstract | Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension, diabetes, and smoking. These conditions are associated with endothelial dysfunction, which itself is associated with reduced endothelial generation of nitric oxide (NO). This is an overview of the implications of NO generation in atherosclerosis and of the potential therapeutic benefit of drugs which donate NO, such as organic nitrates, nicorandil, and sydnonimines, or those which increase the availability of endogenous NO, such as statins, angiotensin-converting enzyme inhibitors, L-arginine, and tetrahydrobiopterin. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://eurheartj.oxfordjournals.org/content/26/19/1945.full.pdf |
| PubMed reference number | 15911567v1 |
| Volume Number | 26 |
| Issue Number | 19 |
| Journal | European heart journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angiotensin-Converting Enzyme Inhibitors Angiotensins Arginine Atherogenesis Atherosclerosis Cessation of life Diabetes Mellitus Elfacos OW 100 Endothelium, Vascular Hypercholesterolemia Hypertensive disease Manuscripts Nicorandil Nitrates Nitric Oxide Donors Preparation Review [Publication Type] Simvastatin Smoke Tetrahydrobiopterin Therapeutic procedure Vascular Diseases |
| Content Type | Text |
| Resource Type | Article |
