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Infarct size measured by single photon emission computed tomographic imaging with (99m)Tc-sestamibi: A measure of the efficacy of therapy in acute myocardial infarction.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gibbons, Raymond J. Miller, Todd L. Christian, Timothy F. |
| Copyright Year | 2000 |
| Abstract | BACKGROUND Use of mortality as an end point in randomized trials of reperfusion therapy requires increasingly large sample sizes to test advances compared with existing therapy, which is already highly effective. There has been a growing interest in infarct size measurements by (99m)Tc-sestamibi SPECT (single photon emission computed tomographic) imaging as a surrogate end point. METHODS AND RESULTS We reviewed the reports published in English regarding infarct size measurements by (99m)Tc-sestamibi. Four separate lines of published evidence support the validity of SPECT imaging with (99m)Tc-sestamibi for determination of infarct size. This end point has been used in a total of 7 randomized trials-1 single center and 6 multicenter. The end point compares favorably with left ventricular function and infarct size measurements with the use of other radiopharmaceuticals. The most important limitation of this approach is the absence thus far of a randomized trial that has shown a corresponding decrease in mortality in association with a therapy that reduces infarct size. CONCLUSIONS SPECT imaging with (99m)Tc-sestamibi is the best available measurement tool for infarct size. It has already served as an end point in early pilot studies to evaluate potential efficacy and in dose-ranging studies. It has the potential to serve as a surrogate end point to uncover advantages of new therapies that may be equivalent to existing therapies with respect to early mortality. |
| Starting Page | 107201 |
| Ending Page | 107201 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/101/1/101.full.pdf?download=true |
| PubMed reference number | 10618311v1 |
| Volume Number | 101 |
| Issue Number | 1 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Left Ventricular Function Myocardial Infarction Photons Radiopharmaceuticals Reperfusion Therapy Sample Size Scientific Publication Single Photon Emission Computed Tomography Computed Tomography Technetium Tc 99m Sestamibi Therapeutic procedure |
| Content Type | Text |
| Resource Type | Article |
