Detection of occult left ventricular dysfunction in patients without prior clinical history of myocardial infarction by technetium‐99m sestamibi myocardial perfusion gated single‐photon emission computed tomography

Content Provider	Scilit
Author	Yao, Siu‐Sun Nichols, Kenneth DePuey, E. Gordon Rozanski, Alan
Copyright Year	2002
Description	Journal: Clinical Cardiology Background: In the absence of a prior history of myocardial infarction (MI), left ventricular (LV) dysfunction is commonly due to hypertension, valvular heart disease, or hibernating myocardium. Hypothesis: Since technetium‐99m sestamibi gated single‐photon emission computed tomography (SPECT) may be used to determine both stress/rest myocardial perfusion and resting LV function, we attempted to evaluate the ability of gated SPECT imaging to detect occult LV dysfunction. Methods: We evaluated the ability of this technique to detect occult LV dysfunction among 179 patients without history MI and angiographically documented coronary artery disease (CAD). All patients underwent both gated SPECT and cardiac catheterization within a 6‐month time period. Left ventricular volume and ejection fraction (EF) values were determined according to a previously validated technique using Simpson's rule. Normal limit values for LV volumes and EF were derived from a control population of 93 patients with normal coronary angiograms. Results: Based on normal limit‐derived criteria, 15% of the CAD study cohort had occult LV dysfunction (> 2 standard deviations below gender‐specific normal limit means for LVEF). Mean LV end‐diastolic volume index (EDVi) was significantly increased (p < 0.05) and LVEF decreased (p < 0.05) in patients with triple‐vessel CAD. End‐diastolic volume index was also increased in the cohort of patients with both hypertension and LV hypertrophy (LVH) (p < 0.05). However, multivariate logistic regression analysis revealed that only CAD extent, but not hypertension or LVH, was a significant predictor of occult LV dysfunction (p = 0.009). Conclusion: Occult LV dysfunction can be detected in patients with CAD by gating technetium‐99m sestamibi SPECT studies, and its presence may signify the presence of extensive CAD.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6654053/pdf
Ending Page	435
Page Count	7
Starting Page	429
e-ISSN	19328737
DOI	10.1002/clc.4960250907
Journal	Clinical Cardiology
Issue Number	9
Volume Number	25
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2002-09-01
Access Restriction	Open
Subject Keyword	Journal: Clinical Cardiology Tc‐99m Myocardial Perfusion Gated Single‐photon Emission Computed Tomography Left Ventricular Volume Left Ventricular Ejection Fraction
Content Type	Text
Resource Type	Article