NDLI: Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2

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Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2

Content Provider	Semantic Scholar
Author	Liang, Yiming Huang, Min Li, Jianwen Sun, Xinlin Jiang, Xiaodan Li, Liangping Ke, Yiquan
Copyright Year	2014
Abstract	Glioblastomas (GBMs) are the most common and aggressive malignant primary brain tumors found in humans. In high-grade gliomas, vasculogenic mimicry (VM) is often detected. VM is the formation of de novo vascular networks by highly invasive tumor cells, instead of endothelial cells. An understanding of the mechanisms of VM formation will contribute to the targeted therapy of GBMs. In the present study, the efficacy of curcumin (CCM) on VM formation and its mechanisms were investigated. It was found that CCM inhibits the VM formation, proliferation, migration and invasion of human glioma U251 cells in a dose-dependent manner. Furthermore, CCM downregulated the protein and mRNA expression of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2, indicating that CCM may function through these factors for the inhibition of VM formation. These data provide novel insights into the use of CCM to antagonize VM, and may contribute to the angiogenesis-targeted therapy of malignant glioma.
Starting Page	1849
Ending Page	1855
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.spandidos-publications.com/ol/8/4/1849/download
PubMed reference number	25202424
Volume Number	8
Journal	Oncology letters
Language	English
Access Restriction	Open
Subject Keyword	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase Brain Neoplasms Curcumin Down-Regulation Endothelial Cells Glioblastoma Impotence, Vasculogenic Liver carcinoma MCC protocol Malignant Glioma Matrix Metalloproteinase 2 Phosphatidylinositols Primary malignant neoplasm of brain U251
Content Type	Text
Resource Type	Article

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