NDLI: Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2.

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Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2.

Content Provider	Europe PMC
Author	LIANG, YIMING HUANG, MIN LI, JIANWEN SUN, XINLIN JIANG, XIAODAN LI, LIANGPING KE, YIQUAN
Copyright Year	2014
Abstract	Glioblastomas (GBMs) are the most common and aggressive malignant primary brain tumors found in humans. In high-grade gliomas, vasculogenic mimicry (VM) is often detected. VM is the formation of de novo vascular networks by highly invasive tumor cells, instead of endothelial cells. An understanding of the mechanisms of VM formation will contribute to the targeted therapy of GBMs. In the present study, the efficacy of curcumin (CCM) on VM formation and its mechanisms were investigated. It was found that CCM inhibits the VM formation, proliferation, migration and invasion of human glioma U251 cells in a dose-dependent manner. Furthermore, CCM downregulated the protein and mRNA expression of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2, indicating that CCM may function through these factors for the inhibition of VM formation. These data provide novel insights into the use of CCM to antagonize VM, and may contribute to the angiogenesis-targeted therapy of malignant glioma.
ISSN	17921074
Journal	Oncology Letters
Volume Number	8
PubMed Central reference number	PMC4156232
Issue Number	4
PubMed reference number	25202424
e-ISSN	17921082
DOI	10.3892/ol.2014.2401
Language	English
Publisher	D.A. Spandidos
Publisher Date	2014-07-31
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright © 2014, Spandidos Publications
Subject Keyword	curcumin glioma matrix metalloproteinase-2 vasculogenic mimicry erythropoietin-producing hepatocellular carcinoma-A2 phosphoinositide 3-kinase
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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