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Tapered-slit Membrane Filter Devices for the High-throughput Viable Isolation of Circulating Tumor Cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kang, Yoon-Tae Cho, Young-Ho |
| Copyright Year | 2014 |
| Abstract | We present tapered-slit filter devices for high-throughput viable circulating tumor cell (CTC) isolation and release. The membrane filter having an array of tapered-slits reduces the cell stress concentration at the edge of slit entrance, thus achieving viable CTC isolation with minimal stress. We fabricated the tapered-slit membrane from the UV exposure of spin-coated SU8 layers. The membrane filter device captures 82.44% of the cancer cells spiked in blood with the cell viability of 72.33% after 5 day culture of the captured cells; thus, allowing further molecular analysis and stable characterization of CTC for cancer diagnosis and prognosis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.rsc.org/images/loc/2014/PDFs/Papers/150_1131.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
