NDLI: Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(i) complexes in A549 lung cancer cells† †Electronic supplementary information (ESI) available. CCDC 1419940 and 1419941. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc0

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Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(i) complexes in A549 lung cancer cells† †Electronic supplementary information (ESI) available. CCDC 1419940 and 1419941. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc0

Content Provider	Semantic Scholar
Author	Arambula, Jonathan F. Mccall, Rosemary Sidoran, K. J. Magda, Darren J. Mitchell, Nate A. Bielawski, Christopher W. Lynch, Vincent Sessler, Jonathan L. Arumugam, Kuppuswamy
Copyright Year	2016
Abstract	Ferrocene containing N-heterocyclic carbene (NHC) ligated gold(I) complexes of the type [Au(NHC)2]+ were prepared and found to be capable of regulating the formation of reactive oxygen species (ROS) via multiple mechanisms. Single crystal X-ray analysis of bis(1-(ferrocenylmethyl)-3-mesitylimidazol-2-ylidene)-gold(I) chloride (5) and bis(1,3-di(ferrocenylmethyl)imidazol-2-ylidene)-gold(I) chloride (6) revealed a quasi-liner geometry around the gold(I) centers, (i.e., the C-Au-C bond angle were measured to be ~177° and all the Au-Ccarbene bonds distances were in the range of 2.00 (7) - 2.03 (1) Å). A series of cell studies indicated that cell proliferation inhibition and ROS generation were directly proportional to amount of ferrocene contained within the [Au(NHC)2]+ complexes (IC50 of 6 < 5 < bis(1-benzyl-3-mesitylimidazol-2-ylidene)-gold(I) chloride (4)). Complexes 4-6 were also confirmed to inhibit thioredoxin reductase as inferred from lipoate reduction assays and increase chelatable intracellular zinc concentrations. RNA microarray gene expression assays revealed that 6 induces endoplasmic reticulum stress response pathways as a result of ROS increase.
Starting Page	1245
Ending Page	1256
Page Count	12
File Format	PDF HTM / HTML
DOI	10.1039/C5SC03519H
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2016/sc/c5sc03519h
Alternate Webpage(s)	https://digitalcommons.georgiasouthern.edu/cgi/viewcontent.cgi?article=1071&context=chem-facpubs
PubMed reference number	26918111
Alternate Webpage(s)	https://doi.org/10.1039/C5SC03519H
Journal	Medline
Volume Number	7
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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