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Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Karimi-Zarchi, Mojgan Moghimi, Mansour Abbasi, Hajar Hadadan, Amaneh Salimi, Erfaneh Morovati-Sharifabad, Majid Akbarian-Bafghi, Mohammad Javad Zare-Shehneh, Masoud Mosavi-Jarrahi, Alireza Neamatzadeh, Hossein |
| Copyright Year | 2019 |
| Abstract | BACKGROUND Previous studies have evaluated the impact of MTHFR 677C>T polymorphism on susceptibility toovarian and cervical cancers in women, but the conclusions are still controversial. To get a more precise evaluation ofthe association between MTHFR 677C>T polymorphism and risk of ovarian and cervical cancers, we performeda meta-analysis of the association of all eligible studies. METHODS A comprehensive search performed in PubMed,Google Scholar, CNKI, and Web of Science databases to identify the relevant studies up to October 15, 2018. Thestrength of the association was estimated by odds ratios (OR) with 95% confidence interval (CI). RESULTS A total of 27case-control studies including eleven studies with 4990 cases 7730 controls on ovarian cancer and 16 studies with 4990cases and 7730 controls on cervical cancer were selected. Pooled data revealed that the MTHFR 677C>T polymorphismnot significantly associated with an increased risk of ovarian and cervical cancers under all five genetic models.However, stratified analysis by ethnicity showed that the MTHFR 677C>T polymorphism was significantly associatedwith risk of ovarian cancer in Asians. No publication bias was found in the current meta-analysis. CONCLUSIONS Theresults of this meta-analysis proposes that the MTHFR 677C>T polymorphism may not play a role in development ofovarian and cervical cancers in overall population. Further well-designed studies are necessary to clarify the preciserole of the MTHFR 677C>T polymorphism on ovarian and cervical cancers risk. |
| Starting Page | 2569 |
| Ending Page | 2577 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.31557/apjcp.2019.20.9.2569 |
| PubMed reference number | 31554347 |
| Journal | Medline |
| Volume Number | 20 |
| Journal | Asian Pacific journal of cancer prevention : APJCP |
| Alternate Webpage(s) | http://journal.waocp.org/article_88718_c600934455eea15d9188e6a17b4bf049.pdf |
| Alternate Webpage(s) | https://doi.org/10.31557/apjcp.2019.20.9.2569 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
