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| Content Provider | Springer Nature Link |
|---|---|
| Author | Pan, Xinwei Lu, Yan Long, Ying Yao, Desheng |
| Copyright Year | 2013 |
| Abstract | Many studies have reported the role of methylenetetrahydrofolate reductase (MTHFR) gene Ala222Val polymorphism with ovary cancer risk, but the results remained controversial. To derive a more precise estimation of the relationship, a meta-analysis was performed. Odds ratios (ORs) with 95 % confidence intervals (CIs) were estimated to assess the association between MTHFR Ala222Val polymorphism and ovary cancer risk. A total of 8 studies including 3,723 cases and 4,001 controls were also involved in this meta-analysis. When all the eligible studies were pooled into this meta-analysis, no significant association between ovary cancer risk and MTHFR Ala222Val polymorphism was found in all genetic models [codominant model: OR = 0.980, 95 % CI = 0.756–1.270, P $_{h}$ = 0.088, P = 0.877; dominant model: OR = 1.022, 95 % CI = 0.864–1.208, P $_{h}$ = 0.033, P = 0.803; recessive model: OR = 1.050, 95 % CI = 0.803–1.373, P $_{h}$ = 0.032, P = 0.723; allele comparison model: OR = 1.028, 95 % CI = 0.898–1.178, P $_{h}$ = 0.012, P = 0.685]. In the stratified analysis by ethnicity, no evidence of any associations of this polymorphism with ovary cancer was found in the Caucasian populations. Our meta-analysis supports that the MTHFR Ala222Val polymorphism is not contributed to the risk of ovary cancer from currently available evidence. |
| Starting Page | 2133 |
| Ending Page | 2139 |
| Page Count | 7 |
| File Format | |
| ISSN | 10104283 |
| Journal | Tumor Biology |
| Volume Number | 35 |
| Issue Number | 3 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2013-10-22 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | MTHFR Polymorphism Ovarian cancer Meta-analysis Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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