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Association of XRCC3 18067 C>T (Thr241Met) polymorphism with risk of cervical and ovarian cancers: A systematic review and meta-analysis.
| Content Provider | Europe PMC |
|---|---|
| Author | Karimi-Zarchi, Mojgan Moghimi, Mansour Abbasi, Hajar Hadadan, Amaneh Tabatabaei, Razieh-Sadat Javaheri, Atiyeh Neamatzadeh, Hossein |
| Copyright Year | 2019 |
| Abstract | The 18067 C>T polymorphism of XRCC3 gene has been considered to be implicated in the development of cervical and ovarian cancers, but the results are inconsistent. Thus, we conducted a meta-analysis to assess the association of XRCC3 18067 C>T polymorphism with risk of cervical and ovarian cancers. All studies on the association of XRCC3 18067 C>T polymorphism with cervical and ovarian cancers risk were retrieved. Finally, a total of 17 studies including 10 studies with 5,637 cases and 10,057 controls on ovarian cancer and 7 studies with 1,112 cases and 1,233 controls on cervical cancer were selected. Overall, pooled results showed that the XRCC3 18067 C>T polymorphism was significantly associated with increased risk of ovarian cancer (TC vs. CC: OR = 0.904, 95% CI = 0.841–0.972, p = 0.006; TT + TC vs. CC: OR = 0.914, 95% CI = 0.853–0.979, p = 0.010) and cervical cancer (TC vs. CC: OR = 1.00, 95% CI = 1.066–1.585, p = 0.009). Further subgroup analysis by ethnicity revealed an increased risk of cervical and ovarian cancer in Asians and Caucasians, respectively. The present meta-analysis inconsistent with the previous meta-analysis suggests that the XRCC3 18067 C>T polymorphism might be implicated in the pathogenesis of cervical and ovarian cancers. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9467339&blobtype=pdf |
| Page Count | 10 |
| ISSN | 20611617 |
| Volume Number | 11 |
| DOI | 10.1556/1646.11.2019.21 |
| PubMed Central reference number | PMC9467339 |
| Issue Number | 3 |
| PubMed reference number | 36343295 |
| Journal | Interventional Medicine & Applied Science [Interv Med Appl Sci] |
| e-ISSN | 20615094 |
| Language | English |
| Publisher | Akadémiai Kiadó |
| Publisher Date | 2019-10-07 |
| Publisher Place | Budapest |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated. © 2019 The Author(s) |
| Subject Keyword | cervical cancer ovarian cancer XRCC3 gene polymorphism meta-analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
