NDLI: Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

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Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

Content Provider	Semantic Scholar
Author	Smith, Heather Lynne Bourne, Jennifer N. Cao, Guan Chirillo, Michael August Ostroff, Linnaea E. Watson, Deborah J. Harris, Kristen M.
Copyright Year	2016
Abstract	Mitochondria support synaptic transmission through production of ATP, sequestration of calcium, synthesis of glutamate, and other vital functions. Surprisingly, less than 50% of hippocampal CA1 presynaptic boutons contain mitochondria, raising the question of whether synapses without mitochondria can sustain changes in efficacy. To address this question, we analyzed synapses from postnatal day 15 (P15) and adult rat hippocampus that had undergone theta-burst stimulation to produce long-term potentiation (TBS-LTP) and compared them to control or no stimulation. At 30 and 120 min after TBS-LTP, vesicles were decreased only in presynaptic boutons that contained mitochondria at P15, and vesicle decrement was greatest in adult boutons containing mitochondria. Presynaptic mitochondrial cristae were widened, suggesting a sustained energy demand. Thus, mitochondrial proximity reflected enhanced vesicle mobilization well after potentiation reached asymptote, in parallel with the apparently silent addition of new dendritic spines at P15 or the silent enlargement of synapses in adults.
Starting Page	401
Ending Page	406
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://sites.cns.utexas.edu/sites/default/files/synapseweb/files/2016_elife_smith_harris_mitochondrial_support_of_presyn_vesicle_in_press.pdf
Alternate Webpage(s)	http://synapseweb.clm.utexas.edu/sites/default/files/synapseweb/files/2016_elife_smith_harris_mitochondrial_support_of_presyn_vesicle.pdf
Alternate Webpage(s)	http://ctcn.utexas.edu/wp-content/uploads/2017/07/2016_elife_smith_harris_mitochondrial_support_of_presyn_vesicle.pdf
PubMed reference number	27991850v1
Alternate Webpage(s)	https://doi.org/10.7554/eLife.15275
DOI	10.7554/elife.15275
Journal	eLife
Volume Number	5
Language	English
Access Restriction	Open
Subject Keyword	Adenosine Triphosphate CA1 field Calcium Contain (action) Dendritic Spines Glutamic Acid Hypertrophy Less Than Long-Term Potentiation Mitochondrial Diseases Mitochondrial Inheritance Mitochondrial cristae Synapses Synaptic Transmission Townes syndrome Vertebral column Vesicle (morphologic abnormality) cetirizine hydrochloride 10 MG Oral Tablet chemosensitization/potentiation
Content Type	Text
Resource Type	Article

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Slow presynaptic and fast postsynaptic components of compound long-term potentiation.

Three-dimensional organization of cell adhesion junctions at synapses and dendritic spines in area CA1 of the rat hippocampus.

Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

Quantitative ultrastructural analysis of hippocampal excitatory synapses.

Principles of long-term dynamics of dendritic spines.

Quantifying the magnitude of changes in synaptic level parameters with long-term potentiation.

Minimum essential factors required for vesicle mobilization at hippocampal synapses.

Long-term depression of presynaptic release from the readily releasable vesicle pool induced by NMDA receptor-dependent retrograde nitric oxide.

Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation.

Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

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