Loading...
Please wait, while we are loading the content...
Similar Documents
Functions of the two glutamate transporters GLAST and GLT-1 in the retina.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Harada, Takayuki Harada, Chikako Watanabe, Masahiko Inoue, Yuichiro Sakagawa, T. Nakayama, Naoki Sasaki, Shoichi Okuyama, Shinichi Watase, Kei Wada, Keiji Tanaka, Kohichi |
| Copyright Year | 1998 |
| Abstract | In the retina, the glutamate transporter GLAST is expressed in Müller cells, whereas the glutamate transporter GLT-1 is found only in cones and various types of bipolar cells. To investigate the functional role of this differential distribution of glutamate transporters, we have analyzed GLAST and GLT-1 mutant mice. In GLAST-deficient mice, the electroretinogram b-wave and oscillatory potentials are reduced and retinal damage after ischemia is exacerbated, whereas GLT-1-deficient mice show almost normal electroretinograms and mild increased retinal damage after ischemia. These results demonstrate that GLAST is required for normal signal transmission between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina. |
| Starting Page | 1 |
| Ending Page | 2 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/95/8/4663.full.pdf |
| PubMed reference number | 9539795v1 |
| Volume Number | 95 |
| Issue Number | 8 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Electroretinography Glutamate Transporter Glutamic Acid Ischemia Membrane Transport Proteins Photoreceptors Retina Retinal Cone SLC1A2 wt Allele SLC1A3 gene retinal damage |
| Content Type | Text |
| Resource Type | Article |
