Loading...
Please wait, while we are loading the content...
Similar Documents
Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Giles, Steven S. Dagenais, Taylor R. T. Botts, Michael Reid Keller, Nancy P. Hull, Christina M. |
| Copyright Year | 2009 |
| Abstract | Cryptococcus neoformans was first described as a human fungal pathogen more than a century ago. One aspect of the C. neoformans infectious life cycle that has been the subject of earnest debate is whether the spores are pathogenic. Despite much speculation, no direct evidence has been presented to resolve this outstanding question. We present evidence that C. neoformans spores are pathogenic in a mouse intranasal inhalation model of infection. In addition, we provide mechanistic insights into spore-host interactions. We found that C. neoformans spores were phagocytosed by alveolar macrophages via interactions between fungal beta-(1,3)-glucan and the host receptors Dectin-1 and CD11b. Moreover, we discovered an important link between spore survival and macrophage activation state: intracellular spores were susceptible to reactive oxygen-nitrogen species. We anticipate these results will serve as the basis for a model to further investigate the pathogenic implications of infections caused by fungal spores. |
| Starting Page | 181 |
| Ending Page | 188 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://iai.asm.org/content/77/8/3491.full.pdf |
| PubMed reference number | 19451235v1 |
| Alternate Webpage(s) | https://doi.org/10.1128/IAI.00334-09 |
| DOI | 10.1128/iai.00334-09 |
| Journal | Infection and immunity |
| Volume Number | 77 |
| Issue Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cryptococcus neoformans Ab:ACnc:Pt:Ser:Qn Cryptococcus neoformans:PrThr:Pt:XXX:Ord:Organism specific culture Infection Inspiration function Lung Diseases, Fungal Macrophage Activation Macrophages, Alveolar Oxygen Pathogenic organism |
| Content Type | Text |
| Resource Type | Article |
