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Signal transduction and amplification through enzyme-triggered ligand release and accelerated catalysis† †Electronic supplementary information (ESI) available: Experimental procedures, compound characterisation data and copies of NMR spectra for novel compounds. See DOI: 10.1039/c5sc01588j Click her
| Content Provider | Semantic Scholar |
|---|---|
| Author | Goggins, Sean P. Marsh, Barrie J. Lubben, Anneke T. Frost, Christopher G. |
| Copyright Year | 2015 |
| Abstract | Signal transduction and signal amplification are both important mechanisms used within biological signalling pathways. Inspired by this process, we have developed a signal amplification methodology that utilises the selectivity and high activity of enzymes in combination with the robustness and generality of an organometallic catalyst, achieving a hybrid biological and synthetic catalyst cascade. A proligand enzyme substrate was designed to selectively self-immolate in the presence of the enzyme to release a ligand that can bind to a metal pre-catalyst and accelerate the rate of a transfer hydrogenation reaction. Enzymetriggered catalytic signal amplification was then applied to a range of catalyst substrates demonstrating that signal amplification and signal transduction can both be achieved through this methodology. |
| Starting Page | 4978 |
| Ending Page | 4985 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29142726 |
| Volume Number | 6 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c5/sc/c5sc01588j/c5sc01588j1.pdf |
| Journal | Chemical Science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
