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Étude de l'impact de la congélation sur les propriétés physico-chimiques des substituts cutanés et caractérisation d'un nouveau modèle de substituts cutanés psoriasiques enrichis en cellules immunitaires produit par génie tissulaire
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dubois-Declercq, Sarah |
| Copyright Year | 2014 |
| Abstract | The current challenge for researchers is to develop new models for more advanced skin substitutes and optimize their production methods to improve reproducibility. This study evaluates the impact of the freezing of skin substitutes at -20°C for 2 months via their physicochemical properties and functionality. The ATR-FTIR analysis show that the cryopreservation did not affect the lipid organization of the stratum corneum while percutaneous absorption analysis show that the freezing of the permeability affects skin substitutes. In addition, the skin model was optimized by incorporating T lymphocytes and to study the role of lymphocytes in cell differentiation of keratinocytes and better understand the role of fractalkine in the development of psoriasis. These results lead us to believe that fractalkine differs from other inflammatory cytokines in the development of psoriasis and should be investigated. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://corpus.ulaval.ca/jspui/bitstream/20.500.11794/24877/1/30684.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
