NDLI: Expression of HLA-G in patients with B-cell chronic lymphocytic leukemia (B-CLL).

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Expression of HLA-G in patients with B-cell chronic lymphocytic leukemia (B-CLL).

Content Provider	Semantic Scholar
Author	Giannopoulos, Krzysztof Dmoszyńska, Anna Bojarska-Junak, Agnieszka Schmitt, Michael Roliński, Jacek
Copyright Year	2008
Abstract	The expression of HLA-G was reported in certain malignancies and its role in escaping from immunosurveillance in cancers was proposed since HLA-G is a nonconventional HLA class I molecule that protects fetus from immunorecognition during pregnancy. Recent studies proposed HLA-G as novel prognostic marker for patients with B-CLL. HLA-G was showed to bear even better prognostic information compared to Zeta-chain associated protein of 70kDa (ZAP-70) and CD38 although some other authors did not find HLA-G expression in CLL. Therefore in this study we characterized the expression of HLA-G on both RNA and protein level. In most of 20 B-CLL patients we were able to detect signal from HLA-G using flow cytometry analysis. The expression of HLA-G was confirmed on messenger level by real-time RT-PCR experiments. No correlation between HLA-G expression and expression of well established prognostic factors such as ZAP-70 and CD38 was detected. These results confirm that HLA-G is expressed on CLL leukemic cells. Furthermore the expression of HLA-G on CLL cells suggests that this molecule might be involved in escaping of CLL cells from immunosurveillance.
File Format	PDF HTM / HTML
DOI	10.2478/v10042-008-0072-x
PubMed reference number	19141398
Journal	Medline
Volume Number	46
Issue Number	4
Alternate Webpage(s)	https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/download/4397/3652
Alternate Webpage(s)	https://doi.org/10.2478/v10042-008-0072-x
Journal	Folia histochemica et cytobiologica
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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