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HLA-G expression is associated with an unfavorable outcome and immunodeficiency in chronic lymphocytic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Nückel, Holger Rebmann, Vera Dürig, Jan Dührsen, Ulrich Grosse-Wilde, Hans |
| Copyright Year | 2005 |
| Description | The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution and exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from antitumor immune responses. The role of HLA-G in B-cell chronic lymphocytic leukemia (B-CLL) has not been defined. HLA-G expression was studied retrospectively in circulating B-CLL cells from 47 patients by flow cytometry using the anti-HLA-E specific monoclonal antibody MEM/G9. The proportion of leukemic cells expressing HLA-G varied from 1% to 54%. Patients with 23% or fewer HLA-G-positive cells (according to receiver operating characteristics [ROC] analysis; designated as HLA-G-negative group) had a significantly longer progression-free survival (PFS) time than patients with more than 23% positive cells (median PFS: 120 versus 23 months; P = .0001). In multivariate analysis, HLA-G expression (hazard ratio: 4.8; P = .002) was an even better independent prognostic factor than the zeta-associated protein 70 (ZAP-70) or CD38 status. Humoral and cellular immunosuppression were significantly more prominent in the HLA-G-positive compared with the HLA-G-negative patient group. In B-CLL, the level of HLA-G expression is correlated with the degree of immunosuppression and prognosis. HLA-G may contribute to the impairment of immune responses against tumor cells and infections. Thus, these findings need to be confirmed in a prospective study. (Blood. 2005;105:1694-1698) |
| Related Links | http://pdfs.semanticscholar.org/d7cf/6561174d933d70e17a6049dd526cf20170eb.pdf |
| Ending Page | 1698 |
| Page Count | 5 |
| Starting Page | 1694 |
| DOI | 10.1182/blood-2004-08-3335 |
| Journal | Blood |
| Issue Number | 4 |
| Volume Number | 105 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2005-02-15 |
| Access Restriction | Open |
| Subject Keyword | Hematology Antigen Multivariate Analysis Antibody Immune Responses Protein Functions Survival Hla G Expression Cll Journal: Blood (Vol- 78, Issue- 4) |
| Content Type | Text |
| Resource Type | Article |
