NDLI: A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging† †Electronic supplementary information (ESI) available: Procedures for synthesis, characterization data, and supplementary figures. See DOI: 10.1039/c9sc02093d

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A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging† †Electronic supplementary information (ESI) available: Procedures for synthesis, characterization data, and supplementary figures. See DOI: 10.1039/c9sc02093d

Content Provider	Semantic Scholar
Author	Wang, Rongchen Chen, Jiyi Zhu, Tianli Gu, Xianfeng Guo, Zhiqian Zhu, Weihong Zhao, Chunchang
Copyright Year	2019
Abstract	The advance of cancer imaging requires innovations to establish novel fluorescent scaffolds that are excitable and emit in the near-infrared region with favorable Stokes shifts. Nevertheless, the lack of probes with these optimized optical properties presents a major bottleneck in targeted cancer imaging. By coupling of boron dipyrromethene platforms to enzymic substrates via a self-immolative benzyl thioether linker, we here report a strategy toward enzyme-activated fluorescent probes to satisfy these requirements. This strategy is applicable to generate various BODIPY-based probes across the NIR spectrum via introducing diverse electron-withdrawing substituents at the 3-position of the BODIPY core through a vinylene unit. As expected, such designed probes show advantages of two-channel ratiometric fluorescence and light-up NIR (I and II) emission with large Stokes shifts upon enzyme activation, enabling targeted cancer cell imaging and accurate tumor location by real-time monitoring of enzyme activities. This strategy is promising in engineering activatable molecular probes suitable for precision medicine.
Starting Page	7222
Ending Page	7227
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1039/C9SC02093D
PubMed reference number	31588290
Alternate Webpage(s)	https://doi.org/10.1039/C9SC02093D
Volume Number	10
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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