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Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc04363a
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lin, Jia-Cheng Zeng, Xiaodong Xiao, Yuling Tang, Lin Nong, Jinxia Liu, Yufang Zhou, Hui Ding, Bingbing Xu, Fuchun Tong, Hanxing Deng, Zixin Xuechuan |
| Copyright Year | 2019 |
| Abstract | Near-infrared II fluorescence imaging holds great promise for in vivo imaging and imaging-guided surgery with deep penetration and high spatiotemporal resolution. However, most NIR-II aromatic luminophores suffer from the notorious aggregation-caused quenching (ACQ) effect in the aqueous solution, which largely hinders their biomedical application in vivo. In this study, the first NIR-II organic aggregation-induced emission (AIE) fluorophore (HLZ-BTED), encapsulated as nanoparticles (HLZ-BTED dots) for in vivo biomedical imaging, was designed and synthesized. The NIR-II AIE HLZ-BTED dots showed high temporal resolution, high photostability, outstanding water-solubility and biocompatibility in vitro and in vivo. The HLZ-BTED dots were further used for long-term breast tumor imaging and visualizing tumor-feeding blood vessels, long-term hind limb vasculature and incomplete hind limb ischemia. More importantly, as a proof-of-concept, this is the first time that non-invasive and real-time NIR-II imaging of the gastrointestinal tract in health and disease has been performed, making the AIE dots a promising tool for gastrointestinal (GI) tract research, such as understanding the healthy status of GI peristalsis, diagnosing and evaluating intestinal motility dysfunction, and assessing drug effects on intestinal obstruction. |
| Starting Page | 1219 |
| Ending Page | 1226 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c8sc04363a |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c8/sc/c8sc04363a/c8sc04363a1.pdf |
| PubMed reference number | 30774922 |
| Alternate Webpage(s) | https://doi.org/10.1039/c8sc04363a |
| Journal | Medline |
| Volume Number | 10 |
| Journal | Chemical science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
