NDLI: Engineering an NIR rhodol derivative with spirocyclic ring-opening activation for high-contrast photoacoustic imaging† †Electronic supplementary information (ESI) available: Procedures for synthesis, characterization data, and supplementary figures. See DOI: 10.1039/c9sc02764e

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Engineering an NIR rhodol derivative with spirocyclic ring-opening activation for high-contrast photoacoustic imaging† †Electronic supplementary information (ESI) available: Procedures for synthesis, characterization data, and supplementary figures. See DOI: 10.1039/c9sc02764e

Content Provider	Semantic Scholar
Author	Liu, Feng Shi, Fu Dong Liu, Xian-Jun Wang, Fenglin Yi, Hai-Bo Jiang, Jianhui
Copyright Year	2019
Abstract	Molecular probes that enable high-contrast photoacoustic (PA) imaging of cellular processes are valuable tools for in vivo studies. Design of activatable PA probes with high contrast remains elusive. We develop a new NIR rhodol derivative, Rhodol-NIR, with a large extinction coefficient, low quantum yield and structural switching from a 'ring-open' form to a 'closed' spirolactone upon esterification. This structural transition, together with the ideal photophysical properties, enables the development of activatable probes for high-contrast PA imaging via a target-specific de-esterification reaction. This strategy is demonstrated using a PA probe designed for a tumor biomarker, human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1), which affords high contrast and excellent sensitivity for PA detection and imaging of hNQO1 in living cells and animals. The strategy can provide a new paradigm for engineering activatable PA probes for high-contrast imaging.
Starting Page	9257
Ending Page	9264
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1039/C9SC02764E
PubMed reference number	32055310
Journal	Medline
Volume Number	10
Alternate Webpage(s)	http://www.rsc.org/suppdata/c9/sc/c9sc02764e/c9sc02764e1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C9SC02764E
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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