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Distinct biological roles for the akt family in mammary tumor progression.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dillon, Rachelle L. Muller, William J. |
| Copyright Year | 2010 |
| Abstract | The phosphatidylinositol 3' kinase/Akt pathway is frequently dysregulated in cancer, which can have unfavorable consequences in terms of cell proliferation, survival, metabolism, and migration. Increasing evidence suggests that Akt1, Akt2, and Akt3 play unique roles in breast cancer initiation and progression. We have recently shown that in contrast to Akt1, which accelerates mammary tumor induction in transgenic mice, Akt2 promotes metastasis of tumor cells without affecting the latency of tumor development. Despite the distinct phenotypic outputs resulting from Akt1 or Akt2 activation, very little is known about the mode by which such unique functions originate from these highly related kinases. Here we discuss potential mechanisms contributing to the differing functional specificity of Akt1 and Akt2 with respect to migration, invasion, and metastasis. |
| Starting Page | 581 |
| Ending Page | 587 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cancerres.aacrjournals.org/content/canres/early/2010/04/27/0008-5472.CAN-10-0266.full.pdf |
| Alternate Webpage(s) | http://cancerres.aacrjournals.org/content/canres/70/11/4260.full.pdf |
| PubMed reference number | 20424120v1 |
| Alternate Webpage(s) | https://doi.org/10.1158/0008-5472.CAN-10-0266 |
| DOI | 10.1158/0008-5472.can-10-0266 |
| Journal | Cancer research |
| Volume Number | 70 |
| Issue Number | 11 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Animal Mammary Neoplasms Cell Proliferation Contribution Proto-Oncogene Proteins c-akt Transcription Initiation Tumor Progression |
| Content Type | Text |
| Resource Type | Article |
