NDLI: Fingermillet bran supplementation alleviates obesity-induced oxidative stress , inflammation and gut microbial derangements in high-fat diet-fed mice

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Fingermillet bran supplementation alleviates obesity-induced oxidative stress , inflammation and gut microbial derangements in high-fat diet-fed mice

Content Provider	Semantic Scholar
Author	Murtaza, Nida Baboota, Ritesh Kumar Jagtap, Sneha C. Singh, Dhirendra Pratap Khare, Pragyanshu Sarma, Siddhartha M. Podili, Koteswaraiah Alagesan, Subramanian Chandra, T. S. Bhutani, Kamlesh Kumar Boparai, Ravneet Kaur Bishnoi, Mahendra Kondepudi, Kanthi Kiran
Copyright Year	2014
Abstract	Several epidemiological studies have shown that the consumption of finger millet (FM) alleviates diabetes-related complications. In the present study, the effect of finger millet whole grain (FM-WG) and bran (FM-BR) supplementation was evaluated in high-fat diet-fed LACA mice for 12 weeks. Mice were divided into four groups: control group fed a normal diet (10 % fat as energy); a group fed a high-fat diet; a group fed the same high-fat diet supplemented with FM-BR; a group fed the same high-fat diet supplemented with FM-WG. The inclusion of FM-BR at 10 % (w/w) in a high-fat diet had more beneficial effects than that of FM-WG. FM-BR supplementation prevented body weight gain, improved lipid profile and anti-inflammatory status, alleviated oxidative stress, regulated the expression levels of several obesity-related genes, increased the abundance of beneficial gut bacteria (Lactobacillus, Bifidobacteria and Roseburia) and suppressed the abundance of Enterobacter in caecal contents (P#0·05). In conclusion, FM-BR supplementation could be an effective strategy for preventing high-fat diet-induced changes and developing FM-BR-enriched functional foods.
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Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114514002396
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/9841C0C48B924CB80DE5DE56924FF473/S0007114514002396a.pdf/finger_millet_bran_supplementation_alleviates_obesityinduced_oxidative_stress_inflammation_and_gut_microbial_derangements_in_highfat_dietfed_mice.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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