NDLI: Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

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Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

Content Provider	MDPI
Author	Groussard, Carole Plissonneau, Claire Josset, Laurie Capel, Fréderic Mura, Mathilde Gouraud, Etienne Mairesse, Guillaume Chesneau, Guillaume Barnich, Nicolas Pialoux, Vincent Boisseau, Nathalie
Copyright Year	2021
Description	High-intensity interval training (HIIT) and linseed oil (LO) supplementation are effective strategies to reduce obesity-induced oxidative stress. Our aim was to determine whether the HIIT + LO combination prevents obesity-induced oxidative stress in high fat diet (HFD)-fed rats. HFD-fed 8-week-old, male, Wistar rats were subdivided in four groups: HFD, LO (2% of sunflower oil replaced with 2% of LO in the HFD), HIIT (4 days/week for 12 weeks), and HIIT + LO. Wistar rats fed a low-fat diet (LFD) were used as controls. Epididymal and subcutaneous adipose tissue, gastrocnemius muscle, liver, and plasma samples were collected to measure oxidative stress markers (AOPP, oxLDL), antioxidant (SOD, CAT, and GPx activities) and pro-oxidant (NOx and XO) enzyme activities. Compared with the LFD, the HFD altered the pro/antioxidant status in different tissues (increase of AOPP, oxLDL, SOD and catalase activities in plasma, and SOD activity increase in liver and decrease in adipose tissues) but not in gastrocnemius. LO upregulated CAT activity and decreased NOx in liver. HIIT alleviated HFD negative effects in liver by reducing SOD and NOx activities. Moreover, the HIIT + LO combination potentiated SOD activity upregulation in subcutaneous tissue. HIIT and LO supplementation have independent beneficial effects on the pro/antioxidant balance. Their association promotes SOD activity in subcutaneous adipose tissue.
Starting Page	3531
e-ISSN	20726643
DOI	10.3390/nu13103531
Journal	Nutrients
Issue Number	10
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-10-09
Access Restriction	Open
Subject Keyword	Nutrients Endocrinology and Metabolism Linseed Oil Supplementation High Intensity Interval Training High Fat Diet Obesity Oxidative Stress
Content Type	Text
Resource Type	Article

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