NDLI: Finger millet bran supplementation alleviates obesity-induced oxidative stress, inflammation and gut microbial derangements in high-fat diet-fed mice

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Finger millet bran supplementation alleviates obesity-induced oxidative stress, inflammation and gut microbial derangements in high-fat diet-fed mice

Content Provider	Scilit
Author	Murtaza, Nida Baboota, Ritesh K. Jagtap, Sneha Singh, Dhirendra P. Khare, Pragyanshu Sarma, Siddhartha M. Podili, Koteswaraiah Alagesan, Subramanian Chandra, T. S. Bhutani, K. K. Boparai, Ravneet K. Bishnoi, Mahendra Kondepudi, Kanthi Kiran
Copyright Year	2014
Description	Several epidemiological studies have shown that the consumption of finger millet (FM) alleviates diabetes-related complications. In the present study, the effect of finger millet whole grain (FM-WG) and bran (FM-BR) supplementation was evaluated in high-fat diet-fed LACA mice for 12 weeks. Mice were divided into four groups: control group fed a normal diet (10 % fat as energy); a group fed a high-fat diet; a group fed the same high-fat diet supplemented with FM-BR; a group fed the same high-fat diet supplemented with FM-WG. The inclusion of FM-BR at 10 % (w/w) in a high-fat diet had more beneficial effects than that of FM-WG. FM-BR supplementation prevented body weight gain, improved lipid profile and anti-inflammatory status, alleviated oxidative stress, regulated the expression levels of several obesity-related genes, increased the abundance of beneficial gut bacteria (Lactobacillus, Bifidobacteria and Roseburia) and suppressed the abundance of Enterobacter in caecal contents (P≤ 0·05). In conclusion, FM-BR supplementation could be an effective strategy for preventing high-fat diet-induced changes and developing FM-BR-enriched functional foods.
Related Links	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/9841C0C48B924CB80DE5DE56924FF473/S0007114514002396a.pdf/div-class-title-finger-millet-bran-supplementation-alleviates-obesity-induced-oxidative-stress-inflammation-and-gut-microbial-derangements-in-high-fat-diet-fed-mice-div.pdf
Ending Page	1458
Page Count	12
Starting Page	1447
ISSN	00071145
e-ISSN	14752662
DOI	10.1017/s0007114514002396
Journal	British Journal Of Nutrition
Issue Number	9
Volume Number	112
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	2014-11-14
Access Restriction	Open
Subject Keyword	British Journal Of Nutrition Nutrition and Dietetics Prebiotic Effects
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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