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Timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open-angle glaucoma or ocular hypertensive patients.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kaluzny, Jakub J. Szaflik, Jerzy Czechowicz-Janicka, Krystyna Kałużny, Józef Orzałkiewicz, Alicja Zaleska, Anna Krajewska, Małgorzata Stewart, Jeanette A. Leech, Jessica N. Stewart, William C. |
| Copyright Year | 2003 |
| Abstract | PURPOSE To establish the efficacy and safety of timolol maleate/dorzolamide fixed combination (TDFC) versus timolol maleate/pilocarpine fixed combination (TPFC), each given twice daily, in primary open-angle glaucoma or ocular hypertensive patients. METHODS In this prospective, multicentred, double-masked trial, 37 patients were treated twice daily with timolol for 4 weeks. They were then randomized to one of the treatment medications for 6 weeks, after which they were treated with timolol again for 2 weeks before being placed on the opposite treatment medication for 6 weeks. RESULTS A total of 36 patients completed the trial. Their mean baseline intraocular pressure (IOP) was 22.3 +/- 3.7 mmHg. Following 6 weeks of treatment, the mean trough (08.00 hours) IOP was 18.0 +/- 2.2 mmHg for TDFC and 17.4 +/- 2.0 mmHg for TPFC (p = 0.22). The mean diurnal curve IOP was 18.1 +/- 2.2 mmHg for TDFC and 16.7 +/- 1.9 mmHg for TPFC (p = 0.0007). At the remaining time-points (10.00, 18.00 and 20.00 hours), TPFC IOPs were statistically lower than TDFC IOPs (p < 0.03). There were statistically more unsolicited reports of vision change and ocular pain associated with TPFC (p = 0.04). Six patients were discontinued early from TPFC therapy (17%) versus two from TDFC (6%) (p = 0.13). CONCLUSIONS This study suggests that TPFC can provide at least a similar efficacious reduction in IOP as TDFC in patients with primary open-angle glaucoma or ocular hypertension. |
| File Format | PDF HTM / HTML |
| DOI | 10.1034/j.1600-0420.2003.00097.x |
| PubMed reference number | 12859261 |
| Journal | Medline |
| Volume Number | 81 |
| Issue Number | 4 |
| Alternate Webpage(s) | https://pillbuys.com/research/Dorzolamide,%20Timolol/5.pdf |
| Journal | Acta ophthalmologica Scandinavica |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
