Efficacy and safety of travoprost/timolol vs dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertension.

Content Provider	Europe PMC
Author	Teus, Miguel A Miglior, Stefano Laganovska, Guna Volksone, Lāsma Romanowska-Dixon, Bozena Gos, Roman Holló, Gábor
Abstract	Purpose:To compare the intraocular pressure- (IOP-) lowering efficacy of fixed combinations travoprost 0.004%/timolol 0.5% and dorzolamide 2%/timolol 0.5% in patients with ocular hypertension or open-angle glaucoma.Methods:In this prospective, multicenter, double-masked, randomized clinical trial, 319 qualifying patients received either travoprost/timolol once daily in the morning (n = 157) or dorzolamide/timolol twice daily (n = 162). IOP was assessed morning and evening at 2 and 6 weeks. The primary outcome measure was mean diurnal IOP.Results:Baseline mean IOP values were similar between groups. Mean pooled diurnal IOP was significantly lower in the travoprost/timolol group (16.5 mmHg ± 0.23) than in the dorzolamide/timolol group (17.3 mmHg ± 0.23; P = 0.011). Mean IOP was significantly lower in the travoprost/timolol group compared to the dorzolamide/timolol group at the 9 AM time point both at Week 2 (P = 0.006) and Week 6 (P = 0.002). The travoprost/timolol combination produced mean IOP reductions from baseline of 35.3% to 38.5%, while the dorzolamide/timolol combination produced mean IOP reductions from baseline of 32.5% to 34.5%.Conclusions:The fixed combination travoprost 0.004%/timolol 0.5% dosed once daily in the morning demonstrated superior mean diurnal IOP-lowering efficacy compared to dorzolamide 2%/timolol 0.5% dosed twice daily in patients with ocular hypertension or open-angle glaucoma.
ISSN	11775467
Volume Number	3
PubMed Central reference number	PMC2788589
PubMed reference number	19997566
Journal	Clinical Ophthalmology (Auckland, N.Z.) [Clin Ophthalmol]
e-ISSN	11775483
Language	English
Publisher	Dove Medical Press
Publisher Date	2009-11-16
Access Restriction	Open
Rights License	This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. © 2009 Teus et al, publisher and licensee Dove Medical Press Ltd.
Subject Keyword	dorzolamide fixed combination glaucoma IOP-lowering therapy timolol travoprost
Content Type	Text
Resource Type	Article
Subject	Ophthalmology