A patient preference comparison of Azarga (brinzolamide/timolol fixed combination) vs Cosopt (dorzolamide/timolol fixed combination) in patients with open-angle glaucoma or ocular hypertension.

Content Provider	Europe PMC
Author	Mundorf, Thomas K Rauchman, Steven H Williams, Robert D Notivol, Ricardo Brinzolamide/Timolol Preference Study Group
Abstract	PurposeTo determine patient preference of and ocular discomfort with fixed combination brinzolamide/timolol compared with fixed combination dorzolamide/timolol.MethodsIn a prospective, double-masked, randomized, active-controlled, crossover, multicenter study, patients received 1 drop of brinzolamide/timolol and dorzolamide/timolol in both eyes on consecutive days in random order. Ocular discomfort was rated 1 minute after instillation of each medication, and preference was noted on Day 2. Adverse events, if any, were solicited at each visit.Results127 subjects with ocular hypertension or open-angle glaucoma were included in the intent-to-treat analysis. Of the 106 subjects who expressed a drug preference, 79.2% preferred brinzolamide/timolol (p < 0.0001). Ocular discomfort scores were significantly higher with dorzolamide/timolol than brinzolamide/timolol (2.9 vs 1.4, respectively; p < 0.0001). Significantly more patients reported ocular pain and discomfort after dorzolamide/timolol instillation and transient blurred vision after brinzolamide/timolol instillation.ConclusionsPatients with ocular hypertension or open-angle glaucoma preferred the brinzolamide/timolol fixed combination over the dorzolamide/timolol fixed combination. This is likely due to the greater ocular discomfort associated with dorzolamide/timolol. The differences in preference, discomfort, and adverse events are likely attributable to formulation differences given the similarities of the active ingredients. Stronger patient preference for brinzolamide/timolol may lead to better therapeutic compliance.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2694004&blobtype=pdf
ISSN	11775467
Journal	Clinical ophthalmology (Auckland, N.Z.) [Clin Ophthalmol]
Volume Number	2
PubMed Central reference number	PMC2694004
Issue Number	3
PubMed reference number	19668763
e-ISSN	11775483
DOI	10.2147/opth.s4088
Language	English
Publisher	Dove Medical Press
Publisher Date	2008-09-01
Access Restriction	Open
Rights License	© 2008 Mundorf et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
Subject Keyword	brinzolamide/timolol dorzolamide/timolol patient preference ocular discomfort open-angle glaucoma or ocular hypertension
Content Type	Text
Resource Type	Article
Subject	Ophthalmology