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Erythrocyte deficiency in calpain inhibitor activity in essential hypertension.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pontremoli, Sandro Melloni, Elisabetta Sparatore, Bianca Salamino, Franca Pontremoli, Roberto Tizianello, A. Barlassina, Cristina Cusi, Daniele Colombo, R. Bianchi, Giampaolo |
| Copyright Year | 1988 |
| Abstract | The calpain-calpain inhibitor system was evaluated in erythrocytes of patients with essential hypertension and normotensive controls, either with or without a family history of hypertension. Calpain levels were similar in the controls and hypertensive patients, whereas the inhibitor activity level was significantly reduced in the latter (301.8 +/- 26.4 vs 220 +/- 14 U/mg hemoglobin, p less than 0.001). Borderline hypertensive patients and a few controls with a history of hypertension showed low inhibitor activity. Similar results have recently been reported in genetically hypertensive rats of the Milan strain. A significant inverse correlation (r = -0.43, p less than 0.001) was found between mean arterial pressure and calpain inhibitor. Although the pathophysiological significance of these observations is not yet clear, they suggest a new area of investigation into the molecular mechanisms underlying essential hypertension and its complications. |
| Starting Page | 283 |
| Ending Page | 290 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/12/5/474.full.pdf |
| Alternate Webpage(s) | https://air.unimi.it/retrieve/handle/2434/205143/239088/474.full.pdf |
| PubMed reference number | 2847982v1 |
| Volume Number | 12 |
| Issue Number | 5 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Erythrocytes Family History Domain Hypertensive disease Patients Pulmonary Hypertension calpain inhibitor activity |
| Content Type | Text |
| Resource Type | Article |
