NDLI: Relationship between axonal collateralization and neuronal degeneration in basal ganglia.

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Relationship between axonal collateralization and neuronal degeneration in basal ganglia.

Content Provider	Semantic Scholar
Author	Parent, Martin Parent, André
Copyright Year	2006
Abstract	In this paper we evaluate the hypothesis of a possible link between the degree of axonal collateralization of neurons located within the different components of basal ganglia and the vulnerability of these neurons to neurodegenerative or neurotoxic events. Our results stemmed from single-cell labeling experiments in rodents and primates, immunohistochemical study of the dopaminergic nigrostriatal pathway in parkinsonian monkeys, and immunocytological analysis of the human striatum in normal individuals and in patients with Huntington's disease. Our results indicate that projection neurons within virtually all basal ganglia components are endowed with a widespread and highly collateralized axon that yields a fixed number of terminals. Such a high degree of axonal collateralization allows exquisitely precise interactions between the various basal ganglia nuclei. However, the maintenance of this unique morphological trait implies high-energy consumption and renders basal ganglia neurons highly vulnerable to neurodegenerative, metabolic or neurotoxic insults.
Starting Page	O3
Ending Page	O3
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://eknygos.lsmuni.lt/springer/340/1.pathology/9%20item.pdf
Alternate Webpage(s)	http://eknygos.lsmuni.lt/springer/340/1.Pathology/9%20Item.pdf
PubMed reference number	17017513v1
Volume Number	70
Journal	Journal of neural transmission. Supplementum
Language	English
Access Restriction	Open
Subject Keyword	Axon Basal Ganglia Contactin 2 Dopamine Hydrochloride Metabolic Process, Cellular Monkeys Neostriatum Neurotoxicity Syndromes Parkinson Disease Patients Primates Rodent
Content Type	Text
Resource Type	Article

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