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Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Brumberg, Joachim Küsters, Sebastian Momani, Ehab Al‐ Marotta, Giorgio Cosgrove, Kelly P. Dyck, Christopher H. Van Herrmann, K. G. Homola, György A. Pezzoli, Gianni Buck, Andreas K. Volkmann, Jens Samnick, Samuel S. Isaias, Ioannis U. |
| Copyright Year | 2017 |
| Abstract | OBJECTIVE To investigate the association between levodopa-induced dyskinesias and striatal cholinergic activity in patients with Parkinson's disease. METHODS This study included 13 Parkinson's disease patients with peak-of-dose levodopa-induced dyskinesias, 12 nondyskinetic patients, and 12 healthy controls. Participants underwent 5-[123I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine single-photon emission computed tomography, a marker of nicotinic acetylcholine receptors, [123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography, to measure dopamine reuptake transporter density and 2-[18F]fluoro-2-deoxyglucose positron emission tomography to assess regional cerebral metabolic activity. Striatal binding potentials, uptake values at basal ganglia structures, and correlations with clinical variables were analyzed. RESULTS Density of nicotinic acetylcholine receptors in the caudate nucleus of dyskinetic subjects was similar to that of healthy controls and significantly higher to that of nondyskinetic patients, in particular, contralaterally to the clinically most affected side. INTERPRETATION Our findings support the hypothesis that the expression of dyskinesia may be related to cholinergic neuronal excitability in a dopaminergic-depleted striatum. Cholinergic signaling would play a role in maintaining striatal dopaminergic responsiveness, possibly defining disease phenotype and progression. |
| Starting Page | 632 |
| Ending Page | 639 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 28904985v1 |
| Alternate Webpage(s) | https://doi.org/10.1002/acn3.438 |
| DOI | 10.1002/acn3.438 |
| Journal | Annals of clinical and translational neurology |
| Volume Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetylcholine Basal Ganglia Caudate nucleus structure Cell Nucleus Cholinergic Receptors Disease Phenotype Dopamine Hydrochloride Dyskinesia, Drug-Induced Levodopa Metabolic Process, Cellular Neostriatum Nicotinic Receptors Parkinson Disease Parkinsonian Disorders Patients Photons Positron-Emission Tomography Positrons Tomography, Emission-Computed Tomography, Emission-Computed, Single-Photon X-Ray Computed Tomography |
| Content Type | Text |
| Resource Type | Article |
