Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment

Content Provider	Semantic Scholar
Author	Takemata, Naomichi Ohta, Kunihiro
Copyright Year	2017
Abstract	Eukaryotic cells produce a variety of non-coding RNAs (ncRNAs), many of which have been shown to play pivotal roles in biological processes such as differentiation, maintenance of pluripotency of stem cells, and cellular response to various stresses. Genome-wide analyses have revealed that many ncRNAs are transcribed around regulatory DNA elements located proximal or distal to gene promoters, but their biological functions are largely unknown. Recently, it has been demonstrated in yeast and mouse that ncRNA transcription around gene promoters and enhancers facilitates DNA binding of transcription factors to their target sites. These results suggest universal roles of promoter/enhancer-associated ncRNAs in the recruitment of transcription factors to their binding sites.
Starting Page	1
Ending Page	5
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/3e/krnb-14-01-1248020.PMC5270525.pdf
PubMed reference number	27763805v1
Alternate Webpage(s)	https://doi.org/10.1080/15476286.2016.1248020
DOI	10.1080/15476286.2016.1248020
Journal	RNA biology
Volume Number	14
Language	English
Access Restriction	Open
Subject Keyword	Auditory recruitment Binding Sites Enhancer of transcription RNA, Untranslated Stem cells TRANSCRIPTION FACTOR dna binding ncRNA transcription non-T, non-B childhood acute lymphoblastic leukemia promoter
Content Type	Text
Resource Type	Article