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Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hoen, Bruno Schaub, Bruno Funk, Anna L. Ardillon, Vanessa Boullard, Manon Cabié, André Callier, Caroline Carles, Georges Cassadou, Sylvie Césaire, Raymond Douine, Maylis Herrmann-Storck, Cécile Kadhel, Philippe Laouénan, Cédric Madec, Yoann Monthieux, Alice Nacher, Mathieu Najioullah, Fatiha Rousset, Dominique Ryan, Catherine O. Schepers, Kinda Maria Stegmann-Planchard, Sofia Tressières, Benoît Voluménie, J. L. Yassinguezo, Samson Janky, Eustase Fontanet, Arnaud |
| Copyright Year | 2018 |
| Abstract | BACKGROUND The risk of congenital neurologic defects related to Zika virus (ZIKV) infection has ranged from 6 to 42% in various reports. The aim of this study was to estimate this risk among pregnant women with symptomatic ZIKV infection in French territories in the Americas. METHODS From March 2016 through November 2016, we enrolled in this prospective cohort study pregnant women with symptomatic ZIKV infection that was confirmed by polymerase-chain-reaction (PCR) assay. The analysis included all data collected up to April 27, 2017, the date of the last delivery in the cohort. RESULTS Among the 555 fetuses and infants in the 546 pregnancies included in the analysis, 28 (5.0%) were not carried to term or were stillborn, and 527 were born alive. Neurologic and ocular defects possibly associated with ZIKV infection were seen in 39 fetuses and infants (7.0%; 95% confidence interval, 5.0 to 9.5); of these, 10 were not carried to term because of termination of pregnancy for medical reasons, 1 was stillborn, and 28 were live-born. Microcephaly (defined as head circumference more than 2 SD below the mean for sex and gestational age) was detected in 32 fetuses and infants (5.8%), of whom 9 (1.6%) had severe microcephaly (more than 3 SD below the mean). Neurologic and ocular defects were more common when ZIKV infection occurred during the first trimester (24 of 189 fetuses and infants [12.7%]) than when it occurred during the second trimester (9 of 252 [3.6%]) or third trimester (6 of 114 [5.3%]) (P=0.001). CONCLUSIONS Among pregnant women with symptomatic, PCR-confirmed ZIKV infection, birth defects possibly associated with ZIKV infection were present in 7% of fetuses and infants. Defects occurred more frequently in fetuses and infants whose mothers had been infected early in pregnancy. Longer-term follow-up of infants is required to assess any manifestations not detected at birth. (Funded by the French Ministry of Health and others; ClinicalTrials.gov number, NCT02916732 .). |
| Starting Page | 985 |
| Ending Page | 994 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://zikalliance.tghn.org/site_media/media/articles/Pregnancy_outcomes_after_ZIKV_infection_in_FTA.pdf |
| PubMed reference number | 29539287v1 |
| Alternate Webpage(s) | https://doi.org/10.1056/NEJMoa1709481 |
| DOI | 10.1056/NEJMoa1709481 |
| Journal | The New England journal of medicine |
| Volume Number | 378 |
| Issue Number | 11 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Abnormalities, Drug-Induced Confidence Intervals Fetus HIV Infections Head circumference Induced abortion (procedure) Infant Microcephaly Polymerase Chain Reaction Pregnancy Zika Virus |
| Content Type | Text |
| Resource Type | Article |
