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Maternal Zika Virus Disease Severity, Virus Load, Prior Dengue Antibodies, and Their Relationship to Birth Outcomes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Halai, Umme-Aiman Nielsen-Saines, Karin Moreira, Maria Elisabeth Lopes Sequeira, Patricia C. De Junior, José Paulo Pereira Zin, Andrea De Araujo Chartrand, Stephen A. Gabaglia, Claudia Raja Gaw, Stephanie L. Adachi, Kristina Tsui, Irena Pilotto, Jose H. Nogueira, Rita Maria Ribeiro Filippis, Ana Maria Bispo De |
| Copyright Year | 2017 |
| Abstract | Background Congenital Zika virus (ZIKV) syndrome is a newly identified condition resulting from infection during pregnancy. We analyzed outcome data from a mother-infant cohort in Rio de Janeiro in order to assess whether clinical severity of maternal ZIKV infection was associated with maternal virus load, prior dengue antibodies, or abnormal pregnancy/infant outcomes. Methods A clinical severity assessment tool was developed based on duration of fever, severity of rash, multisystem involvement, and duration of symptoms during ZIKV infection. ZIKV-RNA load was quantified by polymerase chain reaction (PCR) cycles in blood/ urine. Dengue immunoglobulin G (IgG) antibodies were measured at baseline. Adverse outcomes were defined as fetal loss or a live infant with grossly abnormal clinical or brain imaging findings. Regression models were used to study potential associations. Results 131 ZIKV-PCR positive pregnant women were scored for clinical disease severity, 6 (4.6%) had mild disease, 98 (74.8%) had moderate disease, and 27 (20.6%) severe manifestations of ZIKV infection. There were 58 (46.4%) abnormal outcomes with 9 fetal losses (7.2%) in 125 pregnancies. No associations were found between: disease severity and abnormal outcomes (P = .961; odds ratio [OR]: 1.00; 95% confidence interval [CI]: 0.796-1.270); disease severity and viral load (P = .994); viral load and adverse outcomes (P = .667; OR: 1.02; 95% CI: 0.922-1.135); or existence of prior dengue antibodies (88% subjects) with severity score, ZIKV-RNA load or adverse outcomes (P = .667; OR: 0.78; 95% CI: 0.255-2.397). Conclusions Congenital ZIKV syndrome does not appear to be associated with maternal disease severity, ZIKV-RNA load at time of infection or existence of prior dengue antibodies. |
| Starting Page | 877 |
| Ending Page | 883 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.arca.fiocruz.br/bitstream/icict/19076/2/ve_Halai_U._A._IFF_2017.pdf |
| PubMed reference number | 28535184v1 |
| Alternate Webpage(s) | https://doi.org/10.1093/cid/cix472 |
| DOI | 10.1093/cid/cix472 |
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
| Volume Number | 65 |
| Issue Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Confidence Intervals Dengue Fever Exanthema Fetal Diseases HIV Infections Mental association Odds Ratio Parainfluenza Virus 2, Human Polymerase Chain Reaction RNA Score Single-Chain Antibodies Urinary tract infection Viral load measurement Virus Diseases Zika Virus abnormal pregnancy |
| Content Type | Text |
| Resource Type | Article |
