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Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mao, Yan-Fei Zheng, Xing-Feng Cai, Jian-Mei You, Xin-Min Deng, Xiao-Ming Zhang, John H. Jiang, Lai Sun, Xue-Jun |
| Copyright Year | 2009 |
| Abstract | OBJECTIVE Hydrogen has been reported to selectively reduce the hydroxyl radical, the most cytotoxic of reactive oxygen species. In this study we investigated the effects of hydrogen-rich saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats. METHODS Male Sprague-Dawley rats (n=30, 200-220g) were divided randomly into three experimental groups: sham operated, intestinal I/R plus saline treatment (5ml/kg, i.v.), and intestinal I/R plus hydrogen-rich saline treatment (5ml/kg, i.v.) groups. Intestinal I/R was produced by 90min of intestinal ischemia followed by a 4h of reperfusion. RESULTS Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappaB activation and the pro-inflammatory cytokine interleukin IL-1beta and TNF-alpha in the lung tissues compared with those in saline-treated rat. CONCLUSION Hydrogen-rich saline attenuates lung injury induced by intestinal I/R. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.bbrc.2009.02.105 |
| Alternate Webpage(s) | http://image.sciencenet.cn/olddata/kexue.com.cn/upload/blog/file/2009/2/200922114361113429.fdf.pdf |
| Alternate Webpage(s) | http://image.sciencenet.cn/olddata/kexue.com.cn/upload/blog/file/2009/2/200922885530514900.pdf |
| Alternate Webpage(s) | http://image.sciencenet.cn/olddata/kexue.com.cn/upload/blog/file/2009/3/200932785116663761.pdf |
| PubMed reference number | 19249288 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.bbrc.2009.02.105 |
| Journal | Medline |
| Volume Number | 381 |
| Issue Number | 4 |
| Journal | Biochemical and biophysical research communications |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
