NDLI: Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats

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Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats

Content Provider	Semantic Scholar
Author	Sun, Qiang Kang, Zhimin Cai, Jianmei Liu, Wenwu Zhang, John H. Denoble, Petar J. Tao, Hengyi Sun, Xuejun
Copyright Year	2009
Abstract	Protective effect of hydrogen (H2) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min occlusion of the left anterior descending (LAD) coronary artery and 24-h reperfusion. Intraperitoneal injection of hydrogen-rich saline before reperfusion significantly decreased plasma and myocardium malondialdehyde (MDA) concentration, decreased cardiac cell apoptosis, and myocardial 8-hydroxydeoxyguanosine (8-OHdG) in area at risk zones (AAR), suppressed the activity of caspase-3, and reduced infarct size. The heart function parameters including left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVDP), +(dP/dt)max and −(dP/dt)max were also significantly improved 24 h after reperfusion. It is concluded that hydrogen-rich saline is a novel, simple, safe, and effective method to attenuate myocardial I/R injury.
Starting Page	1212
Ending Page	1219
Page Count	8
File Format	PDF HTM / HTML
DOI	10.3181/0812-RM-349
PubMed reference number	19596825
Journal	Medline
Volume Number	234
Alternate Webpage(s)	http://image.sciencenet.cn/olddata/kexue.com.cn/upload/blog/file/2009/6/200961518112493165.pdf
Alternate Webpage(s)	https://doi.org/10.3181/0812-RM-349
Journal	Experimental biology and medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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