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Rôle du réticulum endoplasmique lors de la phagocytose et l'implication de son recrutement sur les fonctions du phagosome
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gagnon, Étienne |
| Copyright Year | 2007 |
| Abstract | Phagocytosis is a process that allows certain ceils of the immune system to internalize large particulate matter like invading microorganisms in order to kiil and degrade them. The microbicidal properties associated to phagosomes are acquired through a maturation process requiring sequential fusion events with organelles from the endocytic pathway. This allows the acquisition of proteins needed for organelle acidification and many hydrolases responsible for the phagosome’s lytic activity. Phagocytosis represents the first une of defense against infection and plays a crucial role in linking innate and adaptive irnmunity in both cellular and humoral responses. It accomplishes this task by generating peptides from the degradation of internalized microbial proteins and the loading these antigens onto MHC class II molecules in the phagosomes. These presenting molecules are used to activate populations of T CD4 lymphocytes who in turn initiate the process of antibody production and secretion by B lymphocytes. Although the phagosome is a very complex organelle displaying dynamic changes throughout its maturation process. most studies performed on this organelle have used a relatively low number of protein markers. In order to gain a more global view of the molecular machineries associated with this organelle. proteornics analyses of highly enriched preparations of phagosomes were initiated. These analyses have led to the identification of over 150 proteins associated with the phagosorne, many of which were expected to be found in such degradative organelles. Nevertheless, a significant number proteins identified had neyer been shown to play a significant role in phagocytosis. Ibis was the case for several proteins from the endoplasmic reticulum (ER), an organelle normally linked with protein synthesis of lumenal and transmembrane nature. Preliminary resuits published in The Journal of Ccli BioÏogv seemed to show that the presence of these ER markers was not due to contamination. suggesting a possible role for the ER in phagocytosis (Garin et al.. 2001). |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://papyrus.bib.umontreal.ca/xmlui/bitstream/handle/1866/15749/Gagnon_Etienne_2006_these.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
