NDLI: Protective effects from Houttuynia cordata aqueous extract against acetaminophen-induced liver injury

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Protective effects from Houttuynia cordata aqueous extract against acetaminophen-induced liver injury

Content Provider	Semantic Scholar
Author	Chen, Wei-Ting Yang, Chieh-Ling Yin, Mei-Chin
Copyright Year	2014
Abstract	BACKGROUND Protective effects of Houttuynia cordata aqueous extract (HCAE) against acetaminophen-induced hepatotoxicity in Balb/cA mice were examined. METHODS HCAE, at 1 or 2 g/L, was added into the drinking water for 4 weeks. Acute liver injury was induced by acetaminophen treatment intraperitoneally (350 mg/kg body weight). RESULTS Acetaminophen treatment significantly depleted hepatic glutathione (GSH) content, increased hepatic malonyldialdehyde (MDA), reactive oxygen species (ROS) and oxidized glutathione (GSSG) levels, and decreased hepatic activity of glutathione peroxidase (GPX), catalase and superoxide dismutase (SOD) (p<0.05). The pre-intake of HCAE alleviated acetaminophen-induced oxidative stress by retaining GSH content, decreasing MDA, ROS and GSSG production, and maintaining activity of GPX, catalase and SOD in liver (p<0.05). The pre-intake of HCAE also significantly lowered acetaminophen-induced increase in cytochrome P450 2E1 activity (p<0.05). Acetaminophen treatment increased hepatic release of interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein-1 (p<0.05). HCAE intake significantly diminished acetaminophen-induced elevation of these cytokines (p<0.05). CONCLUSION These results support that HCAE could provide hepato-protection.
File Format	PDF HTM / HTML
DOI	10.7603/s40681-014-0005-2
PubMed reference number	25520918
Journal	Medline
Volume Number	4
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/8e/87/40681_2014_Article_5.PMC4264974.pdf
Alternate Webpage(s)	https://doi.org/10.7603/s40681-014-0005-2
Journal	BioMedicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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