NDLI: Aqueous extract of Houttuynia cordata ameliorates aortic endothelial injury during hyperlipidemia via FoxO1 and p38 MAPK pathway

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Aqueous extract of Houttuynia cordata ameliorates aortic endothelial injury during hyperlipidemia via FoxO1 and p38 MAPK pathway

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Ke Cao Chuan Qin Jianshu Liu Jing Liu Jing Gao Weiqiang Lv Xuyun Liu Yan Wang Weijin Zang Jiankang Liu
Abstract	Increasing evidence demonstrates that hyperlipidemia plays a causal role in the development of cardiovascular diseases (CVDs) due to endothelial dysfunction. Houttuynia cordata aqueous extract (HAE), using as both medicine and food, whose effect and mechanism were investigated in endothelial dysfunction. In vivo, it profoundly attenuated hyperlipidemia-induced accumulation of serum metabolites, which in turn contributed to alleviating morphologic and functional damage in vascular endothelium. Moreover, the decrease expression of FoxO1/PGC-1α and mitochondrial complexes in thoracic vessels were ameliorated by HAE administration. Through in vitro cultures, consistently, the results showed that HAE predominantly activated PGC-1α for mitochondrial biogenesis via enhancing FoxO1 expression. Additionally, silencing of FoxO1 remarkably abolished the ability of HAE to augment PGC-1α expression, implying the imperative role of FoxO1 during protection. Besides, the anti-inflammation was mainly mediated via p38 MAPK pathway. Briefly, our study demonstrated that HAE ameliorated hyperlipidemia-induced endothelial injury via upregulating FoxO1/PGC-1α and suppressing p38 MAPK.
Related Links	http://www.sciencedirect.com/science/article/pii/S1756464619304347
ISSN	17564646
e-ISSN	22149414
DOI	10.1016/j.jff.2019.103510
Journal	Journal of Functional Foods
Volume Number	62
Language	English
Publisher	Elsevier
Publisher Date	2019-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Nutrition. Foods and Food Supply Houttuynia Cordata Aqueous Extract Hyperlipidemia Endothelial Dysfunction Mitochondrial Function Foxo1 P38 Mapk
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine Food Science

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