NDLI: Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway.

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Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway.

Content Provider	Europe PMC
Author	Fang, Hao Yang, Zhen Yang, Liu
Copyright Year	2021
Abstract	ObjectiveThis study was to detect the protective effects of Houttuynia cordata extract on the damage induced by propofol in hippocampal neuron of rats.MethodsPropofol-induced neuron injury model and H. cordata extract administration were conducted. Immunofluorescence and immunoblot were conducted for the effect of H. cordata extract on neuronal activity and inflammation were detected in this model.ResultsH. cordata extracts increased neuronal activity, and reduced propofol-induced neuronal inflammation levels. H. cordata extract also reduced propofol-induced neuronal apoptosis. Mechanically, we noticed H. cordata extract activated phosphoinositide 3-kinase/AKT pathway and suppressed Toll-like receptor 4/nuclear factor kappaB pathway, therefore protected propofol-induced injury of rat hippocampal neurons.ConclusionOur findings provide references for anesthetic use in infants and young children.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8048724&blobtype=pdf
ISSN	09594965
Journal	Neuroreport
Volume Number	32
PubMed Central reference number	PMC8048724
Issue Number	7
PubMed reference number	33850081
e-ISSN	1473558X
DOI	10.1097/wnr.0000000000001627
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2021-05-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.
Subject Keyword	Houttuynia cordata extract hippocampal neuron propofol PI3K/AKT pathway Toll-like receptor 4/NF-κB pathway
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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