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One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liao, Han Wang, Ziyi Chen, Song Zhe Ma, Xiaojun Tan, Mingqian |
| Copyright Year | 2015 |
| Abstract | A combination of fluorescence and magnetic resonance imaging (MRI) can provide high-resolution macroscopical anatomical information and high-sensitivity microscopical optical signal simultaneously. In this work, harmless gadolinium(III) doped carbon dots are synthesized in a convenient one-pot hydrothermal approach and used for fluorescence/magnetic resonance multimodal imaging. Unlike typical carbon dots, TEM analysis shows that the carbon dots are particles with irregular shape. Furthermore, Fourier-transform infrared (FTIR) spectra demonstrated structural difference between gadolinium-undoped and doped carbon dots. Nonetheless, the gadolinium-doped carbon dots exhibit strong and stable fluorescence with excitation-dependent emission behavior. Moreover, as an MRI contrast agent, the gadolinium-doped carbon dots represent considerable magnetic resonance properties with a longitudinal relaxation rate of 14.08 mM−1 s−1. In addition, cytotoxicity study reveals that the gadolinium-doped carbon dots show very low toxicity to NCI-H446 cells with an IC50 value of 6.28 mg mL−1. Direct application in cell labeling and in vivo MRI suggests that the gadolinium-doped carbon dots are dual functional fluorescent/MRI probes with excellent biocompatibility. |
| Starting Page | 66575 |
| Ending Page | 66581 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C5RA09948J |
| Volume Number | 5 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c5/ra/c5ra09948j/c5ra09948j1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C5RA09948J |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
