NDLI: Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells.

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Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells.

Content Provider	Semantic Scholar
Author	Chen, Hao Wang, Lina Wang, Zhiying Xie, Yujie Zhang, Zhijun Tang, Yu
Copyright Year	2016
Abstract	The development of multimodal nanoprobes is of great importance in nanomedicine because it integrates the advantages of each imaging modality and offers a significantly enhanced diagnostic effect. In this work, gadolinium(iii) functionalized fluorescent carbon dots (Gd-CDs) are synthesized by means of a one-step hydrothermal approach. As a fluorescent nanomaterial, the obtained Gd-CDs exhibit strong and stable fluorescence with excitation-independent emission behavior. Moreover, as an MRI contrast agent, the Gd-CDs exhibited a longitudinal relaxation rate of 6.06 mM-1 s-1, which is significantly higher than that of the commercially available MRI agent Gadovist (4.24 mM-1 s-1). In addition, the cellular experiment reveals that Gd-CDs promote the proliferation of human mesenchymal stem cells (hMSCs), which is tracked by the fluorescence/Magnetic Resonance dual-modality imaging of hMSCs by the Gd-CDs.
Starting Page	7472
Ending Page	7480
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1039/C6TB01422D
Alternate Webpage(s)	http://www.rsc.org/suppdata/c6/tb/c6tb01422d/c6tb01422d1.pdf
PubMed reference number	32263747
Alternate Webpage(s)	https://doi.org/10.1039/C6TB01422D
Journal	Medline
Volume Number	4
Issue Number	46
Journal	Journal of materials chemistry. B
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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