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Biocompatible carbonized iodine-doped dots for contrast-enhanced CT imaging.
| Content Provider | Europe PMC |
|---|---|
| Author | Jeong, Yohan Jin, Minyoung Kim, Kyoung Sub Na, Kun |
| Abstract | BackgroundComputed tomography (CT) imaging has been widely used for the diagnosis and surveillance of diseases. Although CT is attracting attention due to its reasonable price, short scan time, and excellent diagnostic ability, there are severe drawbacks of conventional CT contrast agents, such as low sensitivity, serious toxicity, and complicated synthesis process. Herein, we describe iodine-doped carbon dots (IDC) for enhancing the abilities of CT contrast agents.MethodIDC was synthesized by one-pot hydrothermal synthesis for 4 h at 180 ℃ and analysis of its structure and size distribution with UV–Vis, XPS, FT-IR, NMR, TEM, and DLS. Furthermore, the CT values of IDC were calculated and compared with those of conventional CT contrast agents (Iohexol), and the in vitro and in vivo toxicities of IDC were determined to prove their safety.ResultsIDC showed improved CT contrast enhancement compared to iohexol. The biocompatibility of the IDC was verified via cytotoxicity tests, hemolysis assays, chemical analysis, and histological analysis. The osmotic pressure of IDC was lower than that of iohexol, resulting in no dilution-induced contrast decrease in plasma.ConclusionBased on these results, the remarkable CT contrast enhancement and biocompatibility of IDC can be used as an effective CT contrast agent for the diagnosis of various diseases compared with conventional CT contrast agents.Supplementary InformationThe online version contains supplementary material available at 10.1186/s40824-022-00277-3. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9233767&blobtype=pdf |
| ISSN | 12264601 |
| Journal | Biomaterials Research [Biomater Res] |
| Volume Number | 26 |
| DOI | 10.1186/s40824-022-00277-3 |
| PubMed Central reference number | PMC9233767 |
| Issue Number | 1 |
| PubMed reference number | 35752823 |
| e-ISSN | 20557124 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2022-06-25 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. © The Author(s) 2022 |
| Subject Keyword | Iodine-doped dots CT imaging Carbon dot One-pot synthesis CT contrast agent |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Medicine Biomaterials Biomedical Engineering |
