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Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ogg, Graham S. Bonhoeffer, Sebastian Dunbar, Paul R. Monard, Simon Cao, Youjia Rowland-Jones, Sarah L. Cerundolo, Vincenzo Hurley, Arlene M. Markowitz, Martin Nixon, Douglas F. McMichael, Andrew J. |
| Copyright Year | 1998 |
| Abstract | Although cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human immunodeficiency virus-type 1 (HIV-1) infection, it has not been possible to demonstrate a direct relation between CTL activity and plasma RNA viral load. Human leukocyte antigen-peptide tetrameric complexes offer a specific means to directly quantitate circulating CTLs ex vivo. With the use of the tetrameric complexes, a significant inverse correlation was observed between HIV-specific CTL frequency and plasma RNA viral load. In contrast, no significant association was detected between the clearance rate of productively infected cells and frequency of HIV-specific CTLs. These data are consistent with a significant role for HIV-specific CTLs in the control of HIV infection and suggest a considerable cytopathic effect of the virus in vivo. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ped.fas.harvard.edu/files/ped/files/science98a_0.pdf |
| Alternate Webpage(s) | http://www.fas.harvard.edu/~ped/people/faculty/publications_nowak/Science98a.pdf |
| PubMed reference number | 9516110v1 |
| Volume Number | 279 |
| Issue Number | 5359 |
| Journal | Science |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cytotoxic T-Lymphocytes HIV Infections HLA Antigens Helper-Inducer T-Lymphocyte Immune complex Immunologic Deficiency Syndromes Leukocytes RNA Viral load measurement Virus Diseases autologous Epstein-Barr virus-specific cytotoxic T lymphocytes (cell) |
| Content Type | Text |
| Resource Type | Article |
