NDLI: Protective Effects of Sodium Selenite and Vitamin E on Mercuric Chloride-Induced Cardiotoxicity in Male Rats

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Protective Effects of Sodium Selenite and Vitamin E on Mercuric Chloride-Induced Cardiotoxicity in Male Rats

Content Provider	Semantic Scholar
Author	Karaboduk, Hatice Uzunhisarcikli, Meltem Kalender, Yusuf
Copyright Year	2015
Abstract	This study was designed to investigate the protective effects of sodium selenite and/or vitamin E against mercuric chloride-induced cardiotoxicity. Male Wistar rats (n=48, 310±10 g) were administered mercuric chloride (1.0 mg/kg bw), sodium selenite (0.25 mg/kg bw), vitamin E (100 mg/kg bw), sodium selenite plus mercuric chloride, vitamin E plus mercuric chloride and sodium selenite plus vitamin E plus mercuric chloride daily via gavage for four weeks. Malondialdehyde (MDA) level, antioxidant enzyme activities [total superoxide dismutase (SOD), catalase (CAT), total glutathione peroxidase (GPx) and total glutathione-S-transferase (GST)], and histopathological changes in the heart tissue were evaluated. Results showed that mercuric chloride exposure resulted in an increase in the MDA level and a decrease in the SOD, CAT, GPx and GST activities, with respect to the control. Light microscopic investigations revealed that mercuric chloride induced histopathological changes in the heart tissue. A significant decrease in the MDA level and a significant increase in the SOD, CAT, GPx and GST activities were observed on the supplementation of sodium selenite and/or vitamin E to mercuric chloride-treated rats, which showed that, sodium selenite and/or vitamin E significantly reduced mercuric chloride induced cardiotoxicity, but not protected completely.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.scielo.br/pdf/babt/v58n2/1516-8913-babt-S1516-8913201400339.pdf
Language	English
Access Restriction	Open
Subject Keyword	3,4-Methylenedioxyamphetamine Antioxidants CATALASE Cardiotoxicity Chloride Ion Free Radicals GLUTATHIONE PEROXIDASE Glutathione S-Transferase Malondialdehyde Mercuric chloride Oxidative Stress Sodium Selenite Superoxide Dismutase Superoxides Transferase Tube feeding of patient Vitamin E mg/kg
Content Type	Text
Resource Type	Article

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