NDLI: Activity-dependent modulation of neurotransmitter innervation to vasopressin neurons of the supraoptic nucleus.

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Activity-dependent modulation of neurotransmitter innervation to vasopressin neurons of the supraoptic nucleus.

Content Provider	Semantic Scholar
Author	Mueller, Nancy K. Di, Shi Paden, Charles M. Herman, James P.
Copyright Year	2005
Abstract	Confocal microscopy was used to assess activity-dependent neuroplasticity in neurotransmitter innervation of vasopressin immunoreactive magnocellular neurons in the supraoptic nucleus (SON). Vesicular glutamate transporter 2, glutamic acid decarboxylase, and dopamine beta-hydroxylase (DBH) synaptic boutons were visualized in apposition to vasopressin neurons in the SON. A decrease in DBH synaptic boutons per cell was seen upon salt loading, indicating diminished noradrenergic/adrenergic innervation. Loss of DBH appositions to vasopressin neurons was associated with a general loss of DBH immunoreactivity in the SON. In contrast, the number of vesicular glutamate transporter 2 synaptic boutons per neuron increased with salt loading, consistent with increased glutamatergic drive of magnocellular SON neurons. Salt loading also caused an increase in the total number of glutamic acid decarboxylase synaptic boutons on vasopressinergic neurons, suggesting enhanced inhibitory innervation as well. These studies indicate that synaptic plasticity compensates for increased secretory demand and may indeed underlie increased secretion, perhaps via neurotransmitter-specific, activity-related changes in synaptic contacts on vasopressinergic magnocellular neurons in the SON.
Starting Page	43
Ending Page	53
Page Count	11
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://endo.endojournals.org/content/146/1/348.full.pdf
PubMed reference number	15388644v1
Volume Number	146
Issue Number	1
Journal	Endocrinology
Language	English
Access Restriction	Open
Subject Keyword	Argipressin Carboxy-Lyases Cell Nucleus Cell secretion Dopamine Glutamate Decarboxylase Glutamate Transporter Glutamic Acid Mixed Function Oxygenases Neuronal Plasticity Neurons Neurotransmitters Presynaptic Terminals Structure of supraoptic nucleus Vasopressin (USP) Vasopressins nerve supply
Content Type	Text
Resource Type	Article

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