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Glutamic acid decarboxylase (GAD) immunocytochemistry of developing rabbit hippocampus.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kunkel, Dennis D. Hendrickson, Anita Schwartzkroin, Philip A. |
| Copyright Year | 1986 |
| Abstract | Immunocytochemical techniques were used to examine the synaptic relations of inhibitory interneurons in the developing rabbit hippocampus. Glutamic acid decarboxylase (GAD), the synthesizing enzyme for the inhibitory neurotransmitter GABA, was found in interneurons of immature (8 d old) as well as mature (30 d old) tissue. GAD-immunoreactivity was seen in somata, dendrites, and axon terminals of interneurons at both ages. Electron-microscopic examination revealed that GAD-positive "terminals" in immature tissue were often not associated with the usual synaptic specializations, but were rather in simple apposition to the "postsynaptic" element. In mature tissue, GAD-positive terminals made symmetric contacts primarily with pyramidal cell somata, initial segments, and proximal dendrites. In addition, GAD-positive terminals synapsed onto both GAD-positive and GAD-negative interneuron profiles. |
| Starting Page | 299 |
| Ending Page | 301 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jneurosci.org/content/jneuro/6/2/541.full.pdf |
| PubMed reference number | 3512793v1 |
| Volume Number | 6 |
| Issue Number | 2 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Axon Carboxy-Lyases Dendrites Generalized Anxiety Disorder Glutamate Decarboxylase Glutamic Acid Immunocytochemistry Interneurons Microscopy Neurotransmitters Presynaptic Terminals Pyramidal Cells Thioctic Acid gamma-Aminobutyric Acid |
| Content Type | Text |
| Resource Type | Article |
