NDLI: ATP-dependent chromatin remodeling and DNA double-strand break repair.

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ATP-dependent chromatin remodeling and DNA double-strand break repair.

Content Provider	Semantic Scholar
Author	Attikum, Haico Van Gasser, Susan M.
Copyright Year	2005
Abstract	The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic stability. Two pathways for the repair of DBSs, nonhomologous end-joining (NHEJ) and homologous recombination (HR), have evolved in eukaryotes. These pathways, like processes such as transcription and replication, act on DNA that is embedded in nucleosomes. Recent studies have shown that DNA repair, like transcription, is facilitated both by histone tail modification and by ATP-dependent chromatin remodeling. This review emphasizes recent reports that demonstrate a function for the ATP-dependent chromatin remodeling complexes INO80 and RSC in NHEJ and HR. We also discuss the possible role of SWR1- and TIP60-mediated nucleosomal histone exchange in DNA repair.
Starting Page	1624
Ending Page	1629
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.fmi.ch/research/groupleader/website/gasserlab/pdfs/van%20Attikum%20Gasser%20Cell%20Cycle%2005.pdf
PubMed reference number	16082209v1
Volume Number	4
Issue Number	8
Journal	Cell cycle
Language	English
Access Restriction	Open
Subject Keyword	DNA Breaks, Double-Stranded DNA Repair Double Strand Break Repair Embedding Histones Homologous Recombination In Situ Nick-End Labeling Non-Homologous DNA End-Joining Nucleosomes Remodels the Structure of Chromatin chromatin remodeling
Content Type	Text
Resource Type	Article

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