NDLI: MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer

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MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer

Content Provider	Semantic Scholar
Author	Gu, Lina Sang, Meixiang Yin, Danjing Liu, Fei Wu, Yunyan Liu, Shina Huang, Weina Shan, Bao-qing
Copyright Year	2018
Abstract	BACKGROUND MAGE-A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE-A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE-A in the peripheral blood of patients with lung cancer. METHODS In this study, we detected MAGE-A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi-nested PCR and analyzed their correlation with clinicopathological risk factors. RESULTS MAGE-A expression was associated with factors indicating poor prognosis. The expression of MAGE-A and each individual MAGE-A gene were also associated with low overall survival in patients with lung cancer. CONCLUSION The expression of MAGE-A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer.
Starting Page	431
Ending Page	438
Page Count	8
File Format	PDF HTM / HTML
PubMed reference number	29430849v1
Alternate Webpage(s)	https://doi.org/10.1111/1759-7714.12571
DOI	10.1111/1759-7714.12571
Journal	Thoracic cancer
Volume Number	9
Language	English
Access Restriction	Open
Subject Keyword	Cancer/Testis Antigen Carcinoma of lung MAGE-A3/12-specific TCR Gene-transduced Autologous PBLs Melanoma-Associated Antigen Family MicroArray and Gene Expression Patients Peripheral Vascular Diseases peripheral blood
Content Type	Text
Resource Type	Article

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