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Pattern and clinical significance of cancer-testis gene expression in head and neck squamous cell carcinoma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cuffel, Cyril Rivals, Jean-Paul Zaugg, Yannick Salvi, Suzanne Seelentag, Walter Speiser, Daniel E. Liénard, Danielle Monnier, Philippe M. Romero, Pedro Bron, Luc P. Rimoldi, Donata |
| Copyright Year | 2011 |
| Abstract | Cancer-testis (CT) antigens comprise families of tumor-associated antigens that are immunogenic in patients with various cancers. Their restricted expression makes them attractive targets for immunotherapy. The aim of this study was to determine the expression of several CT genes and evaluate their prognostic value in head and neck squamous cell carcinoma (HNSCC). The pattern and level of expression of 12 CT genes (MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, MAGE-C2, NY-ESO-1, LAGE-1, SSX-2, SSX-4, BAGE, GAGE-1/2, GAGE-3/4) and the tumor-associated antigen encoding genes PRAME, HERV-K-MEL, and NA-17A were evaluated by RT-PCR in a panel of 57 primary HNSCC. Over 80% of the tumors expressed at least 1 CT gene. Coexpression of three or more genes was detected in 59% of the patients. MAGE-A4 (60%), MAGE-A3 (51%), PRAME (49%) and HERV-K-MEL (42%) were the most frequently expressed genes. Overall, the pattern of expression of CT genes indicated a coordinate regulation; however there was no correlation between expression of MAGE-A3/A4 and BORIS, a gene whose product has been implicated in CT gene activation. The presence of MAGE-A and NY-ESO-1 proteins was verified by immunohistochemistry. Analysis of the correlation between mRNA expression of CT genes with clinico-pathological characteristics and clinical outcome revealed that patients with tumors positive for MAGE-A4 or multiple CT gene expression had a poorer overall survival. Furthermore, MAGE-A4 mRNA positivity was prognostic of poor outcome independent of clinical parameters. These findings indicate that expression of CT genes is associated with a more malignant phenotype and suggest their usefulness as prognostic markers in HNSCC. |
| Starting Page | 147 |
| Ending Page | 159 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://serval.unil.ch/resource/serval:BIB_A0F53B4277B7.P001/REF |
| PubMed reference number | 20715104v1 |
| Alternate Webpage(s) | https://doi.org/10.1002/ijc.25607 |
| DOI | 10.1002/ijc.25607 |
| Journal | International journal of cancer |
| Volume Number | 128 |
| Issue Number | 11 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | BAGE gene CTAG2 gene CTCFL gene Coxsackievirus A4 Ab:ACnc:Pt:CSF:Qn Fifty Nine Forty Nine Gene Expression Genes, vif Immunotherapy MAGE-A3 peptide vaccine Malignant neoplasm of testis Melanoma-Associated Antigen Family Neoplasms PRAME gene Patients RAB8A gene Squamous Epithelial Cells Squamous cell carcinoma of the head and neck Tumor Antigens |
| Content Type | Text |
| Resource Type | Article |
