Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma.

Content Provider	Semantic Scholar
Author	Brisam, Muna Rauthe, Stephan Überla, Klaus Linz, Christian Brands, Roman Camillus Kübler, Alexander Christian Rosenwald, Andreas Müller-Richter, U. D. A.
Copyright Year	2016
Abstract	MAGE-A proteins are highly expressed in oral squamous cell carcinoma (OSCC) and are promising targets for cancer immunotherapy. This study examined the presence of MAGE-A expression within the tumor center (TC) and tumor invasive front (TIF) and evaluated its relationship to poor prognosis. The expression rate of each MAGE-A subtype, A1-A12, was examined in 68 OSCCs at the TIF and TC. Slides (1-µm) of tissue microarrays (diameter =0.6 mm) were immunohistochemically stained, and the findings were correlated to clinical data. Approximately 95% of the tumors had MAGE-A expression. Higher expression in the TC was shown significantly for MAGE-A1, -A5, -A6, -A9 and -A12 (P<0.05). MAGE-A2 and -A3 exhibited the opposite behavior (not significant, P>0.05). Age, tumor size, grade and survival time were not associated with the expression of certain MAGE-A subgroups. When expression in the whole tumor tissue was considered, only MAGE-A1 was expressed at a significantly higher rate in male patients (P=0.034). At the TIF, MAGE-A9 and the UICC disease stage were significantly correlated (P=0.0263), and MAGE-A6 and the UICC disease stage exhibited a strong trend (P=0.0596). The expression of MAGE-A3, -A4, -A5, -A9 and -A11 was significantly associated with lymph node metastasis, while MAGE-A4 was expressed in all regions of the tumors (TIF and TC). This study showed that higher expression of most MAGE-A antigens occurred at the TC rather than at the TIF. MAGE‑A1, -A3, -A4, -A5, -A9 and -A11 were significantly associated with clinically advanced stages of disease and seem to be of particular interest.
Starting Page	1598
Ending Page	1609
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.spandidos-publications.com/or/35/4/1979/download
PubMed reference number	26820613v1
Alternate Webpage(s)	https://doi.org/10.3892/or.2016.4600
DOI	10.3892/or.2016.4600
Journal	Oncology reports
Volume Number	35
Issue Number	4
Language	English
Access Restriction	Open
Subject Keyword	A3 Ag:PrThr:Pt:RBC^donor:Ord Anatomic Node Biomarkers, Tumor Coxsackievirus A1 Ab:ACnc:Pt:Ser:Qn Diameter (qualifier value) Immunotherapy International Union Against Cancer MAGE-A3/12-specific TCR Gene-transduced Autologous PBLs Melanoma-Associated Antigen Family MicroArray and Gene Expression Neoplasms Non-Small Cell Lung Carcinoma Slide (glass microscope) Squamous Epithelial Cells Squamous cell carcinoma lymph node metastases lymph nodes tumor tissue
Content Type	Text
Resource Type	Article